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Increasing the dose of hydrochlorothiazideto 25 mg/day may add approximately 20% to the responders,while at 50 mg/day, 80–90% of possible responders shouldexperience measurable blood pressure decreases.23 A dose of 50mg/day will result in significant hypokalemia (50% or higher)for most patients and may require potassium supplementationor coadministration with a potassium-sparing diuretic.

Alternatively cef-triaxone (1 ? 2 g IV per day) can be administered.

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